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In addition, there were no differences observed between the treatment groups regarding the secondary endpoints of Investigators Global Assessment and Clinicians Erythema Assessment with p-values of 0,86 and 0,50, respectively. Wolbachia load, microfilaremia, antigenemia, and frequency of FDS were significantly reduced in microfilaremic patients up to 24 mo in the doxycycline group compared to the placebo group.